DAB2 Rabbit Monoclonal Antibody

Description

EnkiLife offers the DAB2 Rabbit Monoclonal Antibody. This antibody reacts with Human,Rat species and is suitable for WB,ICC/IF,IP application. Alternative Names of Immunogen: DOC2; DOC-2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50 Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Research Area: Signal Transduction