GENERAL CATALOGUE
Daraxonrasib
HY-148439 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-148439
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Manufacturer product page
medchemexpress.com/rmc-6236.htmlCatalog No: HY-148439
CAS No: 2765081-21-6
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Daraxonrasib RMC-6236 is an orally active, non-covalent RAS ON inhibitor. Daraxonrasib disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. Daraxonrasib inhibits pERK. Daraxonrasib has anti-tumor activity against KRAS mutant tumors.
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