GENERAL CATALOGUE
Darusentan
HY-15404 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-15404
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Catalog No: HY-15404
CAS No: 171714-84-4
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Darusentan Lu-135252 is a selective endothelin receptor A ET-A receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells RAVSMs membranes with single-site kinetics, exhibiting a Ki of 13 nM.
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