dASK1-VHL

Description

dASK1-VHL is an orally active PROTAC degrader targeting ASK1. dASK1-VHL can effectively bind VHL and promote the selective degradation of ASK1. dASK1-VHL effectively reduces ASK1 protein levels, inhibits the activation of p38 MAPK, and reduces liver lipid content. dASK1-VHL provides new ideas for the study of Metabolic dysfunction-associated steatohepatitis MASH Pink: ASK1 ligand 1 HY-174860 ; Blue: E3 ligand S,R,S -AHPC HY-125845 ; Black: Linker, S,R,S -AHPC-CO-C2-PEG-NHCO-C2-COOH HY-174861 .