dCE-2

Description

dCE-2 compound 5 is a PROTAC targeting CREB binding protein CBP and E1A-associated protein EP300 , which was developed based on the crystal structure of bromodomain BRD inhibitors. dCE-2 is composed of E3 ubiquitin ligase ligand Thalidomide-4-OH HY-103596 blue part , PROTAC Linker tert-Butyl 11-aminoundecanoate HY-130715 black part and PROTAC target protein ligand EP300/CBP ligand 2 HY-161960 red part , of which the target protein ligand activity control is EP300/CBP ligand 1 HY-161959 , and the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C10-Boc HY-161961 1 .