GENERAL CATALOGUE
DDO-4033
HY-175247 · 50 mg
MedChemExpress · Cat: HY-175247
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medchemexpress.com/ddo-4033.html
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Catalog No: HY-175247
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
DDO-4033 is a SPOP inhibitor IC50 = 16.9 ?M, Kd = 15.1 ?M . DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma ccRCC cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research.
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