GENERAL CATALOGUE
DeFer-2
HY-175381 · 50 mg
MedChemExpress · Cat: HY-175381
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medchemexpress.com/defer-2.html
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Catalog No: HY-175381
CAS No: 3058911-16-0
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
DeFer-2 is a ferritin PROTAC degrader Kd = 17.1 ?M . DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma. Pink: Oleic acid: HY-N1446, Blue: S,R,S -AHPC: HY-125845, Black: ?-Aminobutyric acid: HY-N0067, Blue + Black: S,R,S -AHPC-C3-NH2: HY-130711 .