(+/-)-Dehydroaltenusin

Description

AAasAasAA+/- -Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase ? pol ? inhibitor with an IC50 of 0.68 ?M. AAasAasAA+/- -Dehydroaltenusin can be isolated from fungus Alternaria tenuis. AAasAasAA+/- -Dehydroaltenusin competitively inhibits the DNA template primer Ki: 0.23 ?M and non-competitively suppresses the 2-deoxyribonucleoside 5-triphosphate substrate Ki: 0.18 ?M . AAasAasAA+/- -Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. AAasAasAA+/- -Dehydroaltenusin can be used for cancers like human adenocarcinoma research.