Deoxypheganomycin D

Description

Deoxypheganomycin D is a specific antimycobacterial inhibitor with no cross-resistance to other antibiotics such as Paromomycin HY-B0956 , Capreomycin HY-P3270 , Viomycin HY-A0155 , Streptothricin HY-129065 , Kanamycin HY-16566 , and Streptomycin HY-B1906 . Deoxypheganomycin D 28 ?M partially inhibits the growth of Mycobacterium 607, with no significant inhibitory effects on DNA, RNA, or protein synthesis. Deoxypheganomycin D 7 ?M affects leucine influx, not thymidine, and has the opposite effect on efflux. The effects of Deoxypheganomycin D may be related to cell membrane and specific mycobacterial lipid components.