DHFR-IN-1

Description

DHFR-IN-1 compound 12 is a potent and selective DHFR dihydrofolate reductase inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin HY-B0330 , where the FIC fractional inhibitory concentration index value is 0.249.