DHFR-IN-22

Description

DHFR-IN-22 Compound 8 is a DHFR Dihydrofolate Reductase inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria NTM , namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 ?g/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 ?g/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections.