DHFR-IN-9

Description

DHFR-IN-9 compound 8A is a dihydrofolate reductase DHFR inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus MRSA ATCC 43300 IC50=0.25 ?g/mL and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it dose: 2.5 mg /kg, 5 mg/kg; ip . DHFR-IN-9 has stronger anticancer activity than paclitaxel Y-B0015 in a mouse model of breast cancer dose: 2.5 mg/kg; ip; once every 3 days .