GENERAL CATALOGUE
DHI1
HY-175261 · 50 mg
MedChemExpress · Cat: HY-175261
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medchemexpress.com/dhi1.html
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Catalog No: HY-175261
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
DHI1 is an anti-leukemia agent with high selectivity for Jurkat IC50 = 21.83 ?M and HL-60 IC50 = 19.14 ?M leukemia cells and has low toxicity to non-cancerous cells. DHI1 can induce G2/M phase cell arrest in Jurkat and HL-60 leukemia cells, as well as S phase arrest in HL-60 cells, and has significant effects on cell cycle signaling molecules Wee1, cyclin B1, cdc2 on Tyr15, and Chk1. DHI1 inhibits the migration and invasion of Jurkat and HL-60 cells by disrupting cytoskeletal actin filaments. DHI1 can be used to study hematological malignancies.
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