GENERAL CATALOGUE
DI-1859
HY-145733 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-145733
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Catalog No: HY-145733
CAS No: 2247061-09-0
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage.
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