Dieugenol

Description

Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances TBARS and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes IC50s=15.1 and 11.5 ?M, respectively but is cytotoxic to NCTC L-929 fibroblasts with a 50 % cytotoxic concentration CC50 value of 58.2 ?M.2 Dieugenol 15 ?M disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species ROS in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.