GENERAL CATALOGUE
Dimethyl 2-oxoglutarate
HY-44134 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-44134
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medchemexpress.com/dimethyl-2-oxoglutarate.htmlCatalog No: HY-44134
CAS No: 13192-04-6
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Dimethyl 2-oxoglutarate Dimethyl ?-ketoglutarate , a cell permeable 2-oxoglutarate derivative, is a tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate serves as a crucial intermediate in the Krebs cycle and an essential nitrogen carrier in metabolic pathways during biological processes. Dimethyl 2-oxoglutarate inhibits autophagy in an IDH1-, IDH2- and ACLY-dependent fashion in cultured human cells. Dimethyl 2-oxoglutarate efficiently prevents autophagy induced by starvation in mice.
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