Dinotefuran

Description

Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors nAChRs . Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to 3H epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to 3H ?-bungarotoxin with an IC50 of 36.1 ?M. Dinotefuran exhibits knockdown activity KD50=0.351 nmol/g and lethal activity LD50=0.173 nmol/g against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects e.g., aphids, planthoppers , while its environmental toxicological effects e.g., oxidative stress and reproductive neurotoxicity on earthworms are also a research focus to assess ecological risks.