DKK2 Mouse Monoclonal Antibody

Description

EnkiLife offers the DKK2 Mouse Monoclonal Antibody. This antibody reacts with Human, Mouse species and is suitable for WB application. Alternative Names of Immunogen: Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1000-1:2000 Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).