GENERAL CATALOGUE
DLL1/Delta1, His, Human
Z05223 · 100 ug
GenScript · Cat: Z05223
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Manufacturer product page
genscript.com/protein/Z05223-DLL1_Delta1_His_Human.htmlCatalog No: Z05223
Category: protein
Pack Size: 100 ug
Brand: GenScript
Description
DLL1, a Notch signaling ligand, is significantly overexpressed in ERalpha luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ERalpha luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands DLL3, JAGGED1, and JAGGED2 do not influence the clinical outcome of ERalpha patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function.
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