GENERAL CATALOGUE
DM4-SMe
HY-130082 · 1 mg
MedChemExpress · Cat: HY-130082
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Catalog No: HY-130082
CAS No: 796073-68-2
Category: Antibody-drug Conjugate ADC Related
Pack Size: 1 mg
Brand: MedChemExpress
Description
DM4-SMe is a metabolite of antibody-maytansin conjugates AMCs and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates ADCs , which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM. DM4-SMe is a highly toxic metabolite that can be oxidized and detoxified by human liver microsomes.
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