DNA PKcs (8D3) Mouse Monoclonal Antibody

Description

EnkiLife offers the DNA PKcs (8D3) Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,ICC/IF,IP application. Alternative Names of Immunogen: PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50 Background: The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties. Research Area: Epigenetics and Nuclear Signaling