GENERAL CATALOGUE
DNL343
HY-149555 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-149555
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Catalog No: HY-149555
CAS No: 2278265-85-1
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
DNL343 is a potent, selective, orally active and brain-penetrant activator of eukaryotic initiation factor eIF2B. DNL343 inhibits the activity of the integrated stress response ISR in the central nervous system CNS and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function LOF mutant mice. DNL343 can be used in the study of neurodegenerative diseases.
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