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Dolutegravir, HIV integrase inhibitor
ab231511 · 5 mg
AB
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Catalog No: ab231511
Category: Biochemicals
Pack Size: 5 mg
Brand: abcam
Description
MW 419.4 Da. Potent HIV integrase inhibitor IC50 = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro . Inhibits HIV-1 viral replication EC50 = 0.51 nM in peripheral blood mononuclear cells PBMCs . Prevents replication of several HIV-1 strains EC50 values of 0.36-2.1 nM that are resistant to nucleoside reverse transcriptase inhibitors NRTIs , non-nucleoside reverse transcriptase inhibitors NNRTIs , and protease inhibitors.
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