GENERAL CATALOGUE
Dolutegravir
HY-13238 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-13238
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Catalog No: HY-13238
CAS No: 1051375-16-6
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Dolutegravir S/GSK1349572 is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir S/GSK1349572 inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants EC50=3.6-5.8 nM .
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