(-)-Domesticine

Description

- -Domesticine is an anti-?-1D-adrenoceptor compound with cytotoxic activity. - -Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. - -Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of - -Domesticine have IC50 values in the range of 23-38 ?M, similar to the known cytotoxic compound etoposide.