Dopamine D3 receptor antagonist-3

Description

Dopamine D3 receptor antagonist-3 is a D3 dopamine receptor D3R -selective positive allosteric modulator PAM -antagonist that can cross the blood-brain barrier. Dopamine D3 receptor antagonist-3 exhibits antagonist activity in the D3R-mediated ?-arrestin recruitment assay with an IC50 and a Kd of 2.5 ?M and 0.49 ?M. amine D3 receptor antagonist-3 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 0.34 ?M. Dopamine D3 receptor antagonist-3 can be used for the study of neuropsychiatric disorders, including substance use disorder.