DOTA-bis(tert-butyl)ester

Description

DOTA-bis tert-butyl ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates RDCs . DOTA-bis tert-butyl ester can be conjugated with different salts to form different metal chelators, such as HY-B1244 hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with 67 Ga-citrate to obtain radiolabeling. When 67 Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.