DOTA-NI-FAPI-04

Description

DOTA-NI-FAPI-04 is a FAP inhibitor IC50 = 7.44 nM . By integrating FAP targeting with hypoxia-sensitive groups nitroimidazole , DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capabilities. DOTA-NI-FAPI-04 chelates metallic isotopes such as 68Ga and 177Lu through DOTA to produce radioactive probes 68Ga Ga/DOTA-NI-FAPI-04 and 177Lu Lu/DOTA-NI-FAPI-04 , which can be used for research in tumor diagnostics and therapeutic agents. DOTA-NI-FAPI-04 holds dual targeting potential in the fields of cancer imaging, tumor microenvironment analysis, and radionuclide therapy, particularly suitable for scenarios where the tumor stroma and hypoxic regions synergistically interact.