GENERAL CATALOGUE
DP-15
HY-168936 · 50 mg
MedChemExpress · Cat: HY-168936
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medchemexpress.com/dp-15.html
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Catalog No: HY-168936
CAS No: 3033837-71-4
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models. Pink: ligand for target protein JQ-1 carboxylic acid HY-78695 ; Black: linker HY-W262798 ; Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH HY-23095
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