GENERAL CATALOGUE
dPDL1-4
HY-174468 · 50 mg
MedChemExpress · Cat: HY-174468
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Manufacturer product page
medchemexpress.com/dpdl1-4.htmlCatalog No: HY-174468
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
dPDL1-4 is a potent and selective eHSPTAC eHSP90 PD-L1 degrader with DC50s of 7.77 ?M and 6.52 ?M in HeLa and B16F10 cells. dPDL1-4 bridges eHSP90 with the target protein, inducing lysosomal degradation. dPDL1-4 can degrade PD-L1 significantly and inhibits tumor growth. dPDL1-4 can be used for the study of cervical cancer and melanoma. Pink: eHSP90 ligand HY-174476 ; Blue: PD-L1 ligand HY-116274 ; Black: Linker HY-W021787 ; HSP ligand + linker: HY-174799 .
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