GENERAL CATALOGUE
DS-437
HY-124131 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-124131
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Catalog No: HY-124131
CAS No: 1674364-87-4
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
DS-437 is a dual PRMT5/7 inhibitor IC50s of PRMT5/7=6 ?M . DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine SAM -competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC50s of 52 and 62 ?M, respectively. DS-437 inhibits the methylation of FOXP3.
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