DU-14 (PTP1B/TC-PTP PROTAC)

Description

DU-14 PTP1B/TC-PTP PROTAC is a potent and selective PTP1B and TC-PTP dual PROTAC degrader. DU-14 PTP1B/TC-PTP PROTAC has the IC50 for PTP1B and TC-PTP phosphatase activity of 24.2 nM and 30.1 nM, respectively. DU-14 PTP1B/TC-PTP PROTAC enhances IFN-? signaling, promotes T cell activation, and has anti-tumor activity. Pink: PTP1B/TC-PTP inhibitor HY-171027 ; Black: Linker HY-W340290 ; Blue: E3 ligand HY-112078 .