Duostatin 5

Description

Duostatin 5 is a ADC Cytotoxin designed based on MMAF HY-15579 and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 ZV05 by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition SPAAC with molecules containing DBCO or BCN groups 1 2 .