GENERAL CATALOGUE
DW18134
HY-161620 · 50 mg
MedChemExpress · Cat: HY-161620
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Catalog No: HY-161620
CAS No: 2626988-87-0
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
DW18134 is an inhibitor for interleukin receptor-associated kinase 4 IRAK 4 with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-? and IL-6. DW18134 attenuates the Lipopolysaccharides HY-D1056 -induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function .
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