(E)-Dothiepin hydrochloride

Description

E -Dothiepin E -Dosulepin; E -Dothep hydrochloride is an antidepressant agent with sedative/anxiolytic activity. E -Dothiepin hydrochloride is an inhibitor preferring of noradrenaline uptake than serotonin uptake. E -Dothiepin hydrochloride facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. E -Dothiepin hydrochloride is also an antagonist of histamine H1-receptor without cardiotoxicity. E -Dothiepin hydrochloride exhibits significant analgesic activity in psychogenic facial pain?idiopathic fibromyalgia syndrome or rheumatoid arthritis.