(E/Z)-4-Hydroxytamoxifen

Description

E/Z -4-Hydroxytamoxifen Afimoxifene is a racemic compound of Z -4-Hydroxytamoxifen and E -4-Hydroxytamoxifen isomers. E/Z -4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen HY-13757A . E/Z -4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor GPER with relatively low affinity 100-1000 nM . E/Z -4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity.