(E/Z)-Icerguastat hydrochloride

Description

E/Z -Icerguastat hydrochloride E/Z -Sephin1 hydrochloride is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2?. E/Z -Icerguastat hydrochloride protects cells from defects in proteostasis. E/Z -Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. E/Z -Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains.