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E6446 dihydrochloride
GENERAL CATALOGUE

E6446 dihydrochloride

HY-12756A · Free Sample (0.1 - 0.2 mg)

MedChemExpress · Cat: HY-12756A

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Catalog No: HY-12756A
CAS No: 1345675-25-3
Category: Immunology Inflammation
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress

Description

E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor KD: 4.61 ?M , significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet HFD -fed mice and may be useful in the study of non-alcoholic fatty liver disease NAFLD .

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