E6446 dihydrochloride (Standard)

Description

E6446 dihydrochloride Standard is the analytical standard of E6446 dihydrochloride . This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor KD: 4.61 ?M , significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet HFD -fed mice and may be useful in the study of non-alcoholic fatty liver disease NAFLD .