GENERAL CATALOGUE
E6446
HY-12756 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-12756
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Catalog No: HY-12756
CAS No: 1219925-73-1
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor KD: 4.61 ?M , significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet HFD -fed mice and may be useful in the study of non-alcoholic fatty liver disease NAFLD .
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