EEA1 (3B7) Rabbit Monoclonal Antibody

Description

EnkiLife offers the EEA1 (3B7) Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,IF,ELISA application. Alternative Names of Immunogen: Early endosome antigen 1; EEA1; MST105; ZFYVE2;. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:100-200;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000; Background: EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes (3). The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin (4-6). Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion (7). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.