EG31

Description

EG31 is an EGFR inhibitor. EG31 effectively inhibits the proliferation of triple-negative breast cancer TNBC cells GI50 values of MDA-MB-231 and Hs578T cells are 498.90 nM and 740.73 nM, respectively and induces apoptosis by inhibiting the EGFR signaling pathway. EG31 still maintains antiproliferative activity against 5-fluorouracil 5-FU -resistant TNBC cells GI50: 519.5 nM . EG31 can be used to study TNBC resistance.