

HY-173188 · 50 mg
MedChemExpress · Cat: HY-173188
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medchemexpress.com/egfr-in-154.htmlDescription
EGFR-IN-154 compound 4c is an EGFR inhibitor with EC50 values of 0.16 ?M, 21.73 ?M and 41.56 ?M against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels.





