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EGFR-IN-154
GENERAL CATALOGUE

EGFR-IN-154

HY-173188 · 50 mg

MedChemExpress · Cat: HY-173188

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Manufacturer product page

medchemexpress.com/egfr-in-154.html
Catalog No: HY-173188
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress

Description

EGFR-IN-154 compound 4c is an EGFR inhibitor with EC50 values of 0.16 ?M, 21.73 ?M and 41.56 ?M against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels.

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