EGFR-IN-156

Description

EGFR-IN-156 Compound 7f is an EGFR inhibitor that also has inhibitory activity against mutations EGFRL858R and EGFRT790M IC50 values are 0.186, 0.131, and 0.107 ?M, respectively . EGFR-IN-156 has significant anticancer activity against human cancer cell lines HepG-29 liver cancer , MCF-7 breast cancer , and HCT-116 colon cancer IC50 values are 1.67, 5.32, and 6.56 ?M, respectively . EGFR-IN-156 inhibits cancer cell proliferation by inducing cell cycle arrest at the G/G1 phase and triggering apoptosis. EGFR-IN-156 shows promise in EGFR-related cancers.