EGFR-IN-57

Description

EGFR-IN-57 Compound 25a is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 AAasAasAAmuM. EGFR-IN-57 also inhibits VEGFR-2, CK2?, topoisomerase II? and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 AAasAasAAmuM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis.