GENERAL CATALOGUE
eIF4A3-IN-18
HY-148452 · 1 mg
MedChemExpress · Cat: HY-148452
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medchemexpress.com/eif4a3-in-18.htmlCatalog No: HY-148452
CAS No: 1402931-84-3
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
eIF4A3-IN-18 compound 74 is a Silvestrol HY-13251 analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis.
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