ELA-32(human) TFA

Description

ELA-32 human TFA is a potent, high affinity apelin receptor agonist IC50=0.27 nM; Kd=0.51 nM . ELA-32 human TFA exhibits no binding GPR15 and GPR25. ELA-32 human TFA activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. ELA-32 human TFA also potentiates the TGF? pathway, priming hESCs toward the endoderm lineage. ELA-32 human TFA stimulates angiogenesis in HUVEC cells.