GENERAL CATALOGUE
ELQ-121
HY-174343 · 50 mg
MedChemExpress · Cat: HY-174343
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medchemexpress.com/elq-121.htmlCatalog No: HY-174343
CAS No: 1228283-36-0
Category: Anti-infection
Pack Size: 50 mg
Brand: MedChemExpress
Description
ELQ-121 is a potent inhibitor of the ubiquinol-oxidation QO -site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research.
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