Emavusertib phosphate

Description

Emavusertib phosphate CA-4948 phosphate is the phosphate salt form of Emavusertib HY-135317 . Emavusertib phosphate is an orally active inhibitor for IRAK4 IC50=57 nM and FLT3. Emavusertib phosphate inhibits NF-?B and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib phosphate exhibits antitumor activity in mouse model.