EMCLL-06 Cells

Description

The EMCLL-06 Cells were derived from IgH.T/IgHTEmu mouse models with sporadic SV40 large T antigen expression in mature B cells. The EMCLL-06 Cells provide an animal model for B-cell Chronic Lymphocytic Leukemia B-CLL . These murine leukemic cells display similar characteristics also found in human B-CLL, in particular in the subgroup of patients with germline IgH V regions associated with poor prognosis. The EMCLL-06 Cells also express a restricted B-cell receptor BCR repertoire with several cases of nearly identical CDR3s. These cells are ideal for studies focusing on B-cell Chronic Lymphocytic Leukemia and the identification of genes that are associated with treatment resistance and poor prognosis.